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1

Probing the selectivity of beta-hydroxylation reactions in non-ribosomal peptide synthesis using analytical ultracentrifugation

Kokona, Bashkim, Winesett, Emily S., Nikolai von Krusenstiern, A., Cryle, Max J., Fairman, Robert, Charkoudian, Louise K.

Journal:

Analytical Biochemistry

Year:

2015

Language:

english

File:

PDF, 4.35 MB

english, 2015

2

Structure of the terminal PCP domain of the non-ribosomal peptide synthetase in teicoplanin biosynthesis

Haslinger, Kristina, Redfield, Christina, Cryle, Max J.

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2015

Language:

english

File:

PDF, 815 KB

english, 2015

3

Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism

Greule, Anja, Stok, Jeanette E., De Voss, James J., Cryle, Max J.

Journal:

Natural Product Reports

Year:

2018

Language:

english

File:

PDF, 3.82 MB

english, 2018

4

Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain

Izoré, Thierry, Tailhades, Julien, Hansen, Mathias Henning, Kaczmarski, Joe A., Jackson, Colin J., Cryle, Max J.

Journal:

Proceedings of the National Academy of Sciences

Year:

2019

Language:

english

File:

PDF, 1.07 MB

english, 2019

5

Is the Ferric Hydroperoxy Species Responsible for Sulfur Oxidation in Cytochrome P450s?

Max J. Cryle, James J. De Voss

Journal:

Angewandte Chemie

Year:

2006

Language:

english

File:

PDF, 93 KB

english, 2006

6

Röntgenkristallstruktur und Mechanismus der DNA-(6-4)-Photolyase

Melanie J. Maul, Thomas R. M. Barends, Andreas F. Glas, Max J. Cryle, Tatiana Domratcheva, Sabine Schneider, Ilme Schlichting, Thomas Carell

Journal:

Angewandte Chemie

Year:

2008

Language:

german

File:

PDF, 1.01 MB

german, 2008

7

Is the Ferric Hydroperoxy Species Responsible for Sulfur Oxidation in Cytochrome P450s?

Max J. Cryle, James J. De Voss

Journal:

Angewandte Chemie International Edition

Year:

2006

Language:

english

File:

PDF, 94 KB

english, 2006

8

Crystal Structure and Mechanism of a DNA (6-4) Photolyase

Melanie J. Maul, Thomas R. M. Barends, Andreas F. Glas, Max J. Cryle, Tatiana Domratcheva, Sabine Schneider, Ilme Schlichting, Thomas Carell

Journal:

Angewandte Chemie International Edition

Year:

2008

Language:

english

File:

PDF, 1.01 MB

english, 2008

9

The Role of the Conserved Threonine in P450BM3 Oxygen Activation: Substrate-Determined Hydroxylation Activity of the Thr268Ala Mutant

Max J. Cryle, James J. De Voss

Journal:

Year:

2008

Language:

english

File:

PDF, 236 KB

english, 2008

10

Reactions Catalyzed by Bacterial Cytochromes P450

Max J. Cryle, Jeanette E. Stok, James J. De Voss

Journal:

Year:

2003

File:

PDF, 53 KB

2003

11

Carbon—Carbon Bond Cleavage by Cytochrome P450BioI (CYP107H1).

Max J. Cryle, James J. De Voss

Journal:

Year:

2004

File:

PDF, 52 KB

2004

12

Cyclopropyl Fatty Acids Implicate a Radical but not a Cation as an Intermediate in P450BM3-Catalyzed Hydroxylations.

Max J. Cryle, Julia M. U. Stuthe, Paul R. Ortiz de Montellano, James J. De Voss

Journal:

Year:

2004

File:

PDF, 79 KB

2004

13

Facile determination of the absolute stereochemistry of hydroxy fatty acids by GC: application to the analysis of fatty acid oxidation by a P450BM3 mutant

Max J. Cryle, James J. De Voss

Journal:

Tetrahedron: Asymmetry

Year:

2007

Language:

english

File:

PDF, 148 KB

english, 2007

14

The stereochemistry of fatty acid hydroxylation by cytochrome P450BM3

Max J. Cryle, Nick J. Matovic, James J. De Voss

Journal:

Tetrahedron Letters

Year:

2007

Language:

english

File:

PDF, 157 KB

english, 2007

15

Arachidonic acid potentiates exocytosis and allows neuronal SNARE complex to interact with Munc18a

Catherine F. Latham, Shona L. Osborne, Max J. Cryle, Frederic A. Meunier

Journal:

Journal of Neurochemistry

Year:

2007

Language:

english

File:

PDF, 783 KB

english, 2007

16

Carrier protein substrates in cytochrome P450-catalysed oxidation

Journal:

Year:

2011

Language:

english

File:

PDF, 2.41 MB

english, 2011

17

Functional expression and characterization of cytochrome P450 52A21 from Candida albicans

Donghak Kim, Max J. Cryle, James J. De Voss, Paul R. Ortiz de Montellano

Journal:

Archives of Biochemistry and Biophysics

Year:

2007

Language:

english

File:

PDF, 1.27 MB

english, 2007

18

Structural characterization of CYP165D3, a cytochrome P450 involved in phenolic coupling in teicoplanin biosynthesis

Max J. Cryle, Jessica Staaden, Ilme Schlichting

Journal:

Archives of Biochemistry and Biophysics

Year:

2011

Language:

english

File:

PDF, 1.58 MB

english, 2011

19

Enzyme-Substrate Complementarity Governs Access to a Cationic Reaction Manifold in the P450 BM3 -Catalysed Oxidation of Cyclopropyl Fatty Acids

Cryle, Max J., Hayes, Patricia Y., De Voss, James J.

Journal:

Chemistry - A European Journal

Year:

2012

Language:

english

File:

PDF, 453 KB

english, 2012

20

Crystal Structures of Substrate-Free and Retinoic Acid-Bound Cyanobacterial Cytochrome P450 CYP120A1 †‡

Kühnel, Karin, Ke, Na, Cryle, Max J., Sligar, Stephen G., Schuler, Mary A., Schlichting, Ilme

Journal:

Year:

2008

Language:

english

File:

PDF, 7.23 MB

english, 2008

21

Cytochrome P450 sky Interacts Directly with the Nonribosomal Peptide Synthetase to Generate Three Amino Acid Precursors in Skyllamycin Biosynthesis

Uhlmann, Stefanie, Süssmuth, Roderich D., Cryle, Max J.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.53 MB

english, 2013

22

A Facile Fmoc Solid Phase Synthesis Strategy To Access Epimerization-Prone Biosynthetic Intermediates of Glycopeptide Antibiotics

Brieke, Clara, Cryle, Max J.

Journal:

Organic Letters

Year:

2014

Language:

english

File:

PDF, 1.91 MB

english, 2014

23

The Structure of a Transient Complex of a Nonribosomal Peptide Synthetase and a Cytochrome P450 Monooxygenase

Haslinger, Kristina, Brieke, Clara, Uhlmann, Stefanie, Sieverling, Lina, Süssmuth, Roderich D., Cryle, Max J.

Journal:

Angewandte Chemie International Edition

Year:

2014

Language:

english

File:

PDF, 1.55 MB

english, 2014

24

Cyclopropyl Containing Fatty Acids as Mechanistic Probes for Cytochromes P450

Cryle, Max J., Ortiz de Montellano, Paul R., De Voss, James J.

Journal:

Journal of Organic Chemistry

Year:

2005

Language:

english

File:

PDF, 314 KB

english, 2005

25

Products of Cytochrome P450 BioI (CYP107H1)-Catalyzed Oxidation of Fatty Acids

Cryle, Max J., Matovic, Nick J., De Voss, James J.

Journal:

Organic Letters

Year:

2003

Language:

english

File:

PDF, 80 KB

english, 2003

26

Structural and Biochemical Characterization of the Cytochrome P450 CypX (CYP134A1) from Bacillus subtilis : A Cyclo- l -leucyl- l -leucyl Dipeptide Oxidase

Cryle, Max J., Bell, Stephen G., Schlichting, Ilme

Journal:

Year:

2010

Language:

english

File:

PDF, 3.46 MB

english, 2010

27

Are branched chain fatty acids the natural substrates for P450BM3?

Cryle, Max J., Espinoza, Rocio D., Smith, Sarah J., Matovic, Nicholas J., De Voss, James J.

Journal:

Chemical Communications

Year:

2006

Language:

english

File:

PDF, 323 KB

english, 2006

28

Carbon?carbon bond cleavage by cytochrome P450BioI (CYP107H1)Electronic Supplementary Information (ESI) available: 2, R 2, S 2, 4, SS 6b, RR 6b characterisation and synthesis. Enzymatic oxidation and analysis protocols. See http://www.rsc.org/suppdata/cc/b3/b311652b/

Cryle, Max J., De Voss, James J.

Journal:

Chemical Communications

Year:

2004

Language:

english

File:

PDF, 202 KB

english, 2004

29

Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450BM3-catalysed hydroxylationsElectronic Supplementary Information (ESI) available: Cationic rearrangement of 3, spectra of 3, 5, 7, 11?12, plus GCMS conditions for analysis of 1?5, 7?12. See http://www.rsc.org/suppdata/cc/b3/b315911f/

Cryle, Max J., Stuthe, Julia M. U., Ortiz de Montellano, Paul R., De Voss, James J.

Journal:

Chemical Communications

Year:

2004

Language:

english

File:

PDF, 107 KB

english, 2004

30

Cytochrome P450 OxyB tei Catalyzes the First Phenolic Coupling Step in Teicoplanin Biosynthesis

Haslinger, Kristina, Maximowitsch, Egle, Brieke, Clara, Koch, Alexa, Cryle, Max J.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.50 MB

english, 2014

31

Die Struktur eines transienten Komplexes einer nicht-ribosomalen Peptidsynthetase mit einer P450-Monooxygenase

Haslinger, Kristina, Brieke, Clara, Uhlmann, Stefanie, Sieverling, Lina, Süssmuth, Roderich D., Cryle, Max J.

Journal:

Angewandte Chemie

Year:

2014

Language:

german

File:

PDF, 1.55 MB

german, 2014

32

Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics

Brieke, Clara, Kratzig, Veronika, Haslinger, Kristina, Winkler, Andreas, Cryle, Max J.

Journal:

Organic & Biomolecular Chemistry

Year:

2015

Language:

english

File:

PDF, 1.32 MB

english, 2015

33

The crystal structure of the versatile cytochrome P450 enzyme CYP109B1 from Bacillus subtilis

Zhang, Aili, Zhang, Ting, Hall, Emma A., Hutchinson, Sean, Cryle, Max J., Wong, Luet-Lok, Zhou, Weihong, Bell, Stephen G.

Journal:

Molecular BioSystems

Year:

2015

Language:

english

File:

PDF, 4.22 MB

english, 2015

34

X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis

Haslinger, Kristina, Peschke, Madeleine, Brieke, Clara, Maximowitsch, Egle, Cryle, Max J.

Journal:

Year:

2015

Language:

english

File:

PDF, 5.52 MB

english, 2015

35

The archaeal cofactor F 0 is a light-harvesting antenna chromophore in eukaryotes

Glas, Andreas F., Maul, Melanie J., Cryle, Max, Barends, Thomas R. M., Schneider, Sabine, Kaya, Emine, Schlichting, Ilme, Carell, Thomas

Journal:

Proceedings of the National Academy of Sciences

Year:

2009

Language:

english

File:

PDF, 1.30 MB

english, 2009

36

Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products

Al Toma, Rashed S., Brieke, Clara, Cryle, Max J., Süssmuth, Roderich D.

Journal:

Natural Product Reports

Year:

2015

Language:

english

File:

PDF, 2.70 MB

english, 2015

37

Design and synthesis of peptide inhibitor conjugates as probes of the Cytochrome P450s from glycopeptide antibiotic biosynthesis

Brieke, Clara, Maier, Theresa, Schröter, Martin, Cryle, Max J.

Journal:

Year:

2016

Language:

english

File:

PDF, 2.13 MB

english, 2016

38

Reactions Catalyzed by Bacterial Cytochromes P450

Cryle, Max J., Stok, Jeanette E., De Voss, James J.

Journal:

Australian Journal of Chemistry

Year:

2003

Language:

english

File:

PDF, 219 KB

english, 2003

39

Coulomb explosion imaging of small organic molecules at LCLS

Erk, Benjamin, Rudenko, Artem, Rolles, Daniel, Rudek, Benedikt, Foucar, Lutz, Epp, Sascha, Cryle, Max, Schlichting, Ilme, Bostedt, Christoph, Schorb, Sebastian, Bozek, John, Rouzee, Arnaud, Hundertmar

Journal:

Journal of Physics Conference Series

Year:

2012

Language:

english

File:

PDF, 402 KB

english, 2012

40

Regulation of the P450 Oxygenation Cascade Involved in Glycopeptide Antibiotic Biosynthesis

Peschke, Madeleine, Haslinger, Kristina, Brieke, Clara, Reinstein, Jochen, Cryle, Max J.

Journal:

Journal of the American Chemical Society

Year:

2016

Language:

english

File:

PDF, 1.78 MB

english, 2016

41

Capturing the Structure of the Substrate Bound Condensation Domain

Kittilä, Tiia, Cryle, Max J.

Journal:

Cell Chemical Biology

Year:

2016

Language:

english

File:

PDF, 363 KB

english, 2016

42

Sequential In Vitro Cyclization by Cytochrome P450 Enzymes of Glycopeptide Antibiotic Precursors Bearing the X-Domain from Nonribosomal Peptide Biosynthesis

Brieke, Clara, Peschke, Madeleine, Haslinger, Kristina, Cryle, Max J.

Journal:

Angewandte Chemie

Year:

2015

Language:

english

File:

PDF, 2.94 MB

english, 2015

43

Online Pyrophosphate Assay for Analyzing Adenylation Domains of Nonribosomal Peptide Synthetases

Kittilä, Tiia, Schoppet, Melanie, Cryle, Max J.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.32 MB

english, 2016

44

Sequential In Vitro Cyclization by Cytochrome P450 Enzymes of Glycopeptide Antibiotic Precursors Bearing the X-Domain from Nonribosomal Peptide Biosynthesis

Brieke, Clara, Peschke, Madeleine, Haslinger, Kristina, Cryle, Max J.

Journal:

Angewandte Chemie International Edition

Year:

2015

Language:

english

File:

PDF, 2.96 MB

english, 2015

45

Structure of OxyA tei : completing our picture of the glycopeptide antibiotic producing Cytochrome P450 cascade

Haslinger, Kristina, Cryle, Max J., Cogdell, Richard

Journal:

Year:

2016

Language:

english

File:

PDF, 1.10 MB

english, 2016

46

New Structural Data Reveal the Motion of Carrier Proteins in Nonribosomal Peptide Synthesis

Kittilä, Tiia, Mollo, Aurelio, Charkoudian, Louise K., Cryle, Max J.

Journal:

Angewandte Chemie International Edition

Year:

2016

Language:

english

File:

PDF, 2.64 MB

english, 2016

47

More than just recruitment: the X-domain influences catalysis of the first phenolic coupling reaction in A47934 biosynthesis by Cytochrome P450 StaH

Kratzig, Veronika, Peschke, Madeleine, Brieke, Clara, Cryle, Max

Journal:

Molecular BioSystems

Year:

2016

Language:

english

File:

PDF, 1.80 MB

english, 2016

48

Selectivity in a barren landscape: the P450 BioI –ACP complex

Journal:

Biochemical Society Transactions

Year:

2010

Language:

english

File:

PDF, 407 KB

english, 2010

49

Understanding the crucial interactions between Cytochrome P450s and non-ribosomal peptide synthetases during glycopeptide antibiotic biosynthesis

Peschke, Madeleine, Gonsior, Melanie, Süssmuth, Roderich D, Cryle, Max J

Journal:

Current Opinion in Structural Biology

Year:

2016

Language:

english

File:

PDF, 2.49 MB

english, 2016

50

Neue Strukturdaten geben Einblick in die Bewegungen von Transportproteinen in der nicht-ribosomalen Peptidsynthese

Kittilä, Tiia, Mollo, Aurelio, Charkoudian, Louise K., Cryle, Max J.

Journal:

Angewandte Chemie

Year:

2016

File:

PDF, 4.88 MB

2016